Weekend Box Office
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| 1 | The Town | 23.800 | 3 | NEW | 2861 | 8,319 | 23.800 |
| 2 | Easy A | 18.200 | 3 | NEW | 2856 | 6,373 | 18.200 |
| 3 | Devil | 12.584 | 3 | NEW | 2809 | 4,480 | 12.584 |
| 4 | Resident Evil 4 | 10.100 | 10 | -62% | 3209 | 3,147 | 44.000 |
| 5 | Alpha and Omega | 9.200 | 3 | NEW | 2625 | 3,505 | 9.200 |
| 6 | Takers | 3.000 | 24 | -47% | 2139 | 1,403 | 52.300 |
| 7 | The American | 2.756 | 19 | -51% | 2457 | 1,122 | 32.856 |
| 8 | Inception | 2.015 | 66 | -28% | 1305 | 1,544 | 285.178 |
| 9 | The Other Guys | 2.000 | 45 | -40% | 1827 | 1,095 | 115.400 |
| 10 | Machete | 1.700 | 17 | -60% | 1704 | 998 | 24.300 |
| 11 | Eat, Pray, Love | 1.700 | 38 | -42% | 1668 | 1,019 | 77.700 |
| 12 | The Expendables | 1.400 | 38 | -57% | 1854 | 755 | 101.000 |
| 13 | Going the Distance | 1.320 | 17 | -65% | 2007 | 658 | 16.736 |
| 14 | The Last Exorcism | 1.250 | 24 | -62% | 2013 | 621 | 40.150 |
| 15 | Nanny McPhee 2 | 0.985 | 31 | -53% | 1588 | 620 | 27.330 |
| 16 | The Switch | 0.926 | 31 | -54% | 1158 | 800 | 26.597 |
| 17 | Despicable Me | 0.873 | 73 | -47% | 944 | 925 | 244.701 |
| 18 | Get Low | 0.678 | 52 | -22% | 467 | 1,452 | 7.911 |
| 19 | Lottery Ticket | 0.613 | 31 | -49% | 677 | 905 | 23.493 |
| 20 | Vampires Suck | 0.570 | 33 | -62% | 964 | 591 | 35.867 |
Top 10 Grossed: $85.355 million In 2008, 27 weekends grossed more, 11 grossed less
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